InterPAD - DETAILS

cuprous ion, Copper(1+), Copper(I), 17493-86-6, Copper(1+)ions, Helixate, Kogenate, cuprous copper, Obizur, Cuprous cation, Octocog alfa, Helixate NexGen, Helixate FS, Kogenate FS, Copper(I) ion, copper (I), Copper ion(1+), copper (1), Copper ion (Cu+), copper (+1), Cuprous ion (Cu1+), Copper, ion (Cu1+), Cu(I), Octocog alfa [INN:BAN], Cu1+, Bay-w 6240, UNII-P89DR4NY54, Cu(+), P89DR4NY54, BAY w 6240, CHEBI:49552, DTXSID30169912, VMQMZMRVKUZKQL-UHFFFAOYSA-N, Copper, ion (Cu1+) (8CI,9CI), BAY-14-2222, Q27104705, Blood-coagulation factor VIII (human), glycoform alpha, 139076-62-3

No.	Title	Href
1	Antitumor Activity of Copper (I)-Nicotinate Complex and Autophagy Modulation in HCC1806 Breast Cancer Cells. Anticancer Agents Med Chem. 2017 Nov 24;17(11):1526-1536. doi: 10.2174/1871520617666170327144122.	`Click`

No.

Title

Href

Antitumor Activity of Copper (I)-Nicotinate Complex and Autophagy Modulation in HCC1806 Breast Cancer Cells. Anticancer Agents Med Chem. 2017 Nov 24;17(11):1526-1536. doi: 10.2174/1871520617666170327144122.

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Name	Copper (I)
PubChem CID	104815
Molecular Weight	63.55g/mol
Synonyms	cuprous ion, Copper(1+), Copper(I), 17493-86-6, Copper(1+)ions, Helixate, Kogenate, cuprous copper, Obizur, Cuprous cation, Octocog alfa, Helixate NexGen, Helixate FS, Kogenate FS, Copper(I) ion, copper (I), Copper ion(1+), copper (1), Copper ion (Cu+), copper (+1), Cuprous ion (Cu1+), Copper, ion (Cu1+), Cu(I), Octocog alfa [INN:BAN], Cu1+, Bay-w 6240, UNII-P89DR4NY54, Cu(+), P89DR4NY54, BAY w 6240, CHEBI:49552, DTXSID30169912, VMQMZMRVKUZKQL-UHFFFAOYSA-N, Copper, ion (Cu1+) (8CI,9CI), BAY-14-2222, Q27104705, Blood-coagulation factor VIII (human), glycoform alpha, 139076-62-3
Drug Type	Small molecule
Formula	Cu+
SMILES	[Cu+]
InChI	1S/Cu/q+1
InChIKey	VMQMZMRVKUZKQL-UHFFFAOYSA-N
CAS Number	17493-86-6
ChEBI ID	CHEBI:49552
Toxicity	Organism	Test Type	Route(Dose)
Structure			Download 2D MOL 3D MOL

Pair Name	Nicotinic acid, Copper (I)
Partner Name	Nicotinic acid
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Expression	MAP1LC3A	hsa84557
Gene Regulation	Up-regulation	Expression	NBR1	hsa4077
In Vitro Model	HCC1806	Breast squamous cell carcinoma, acantholytic variant	Homo sapiens (Human)	CVCL_1258
In Vitro Model	MDA-MB-231	Breast adenocarcinoma	Homo sapiens (Human)	CVCL_0062
Result	CNC restrained the growth, in a dose-dependent manner, and induced cell death in human HCC1806 cell line. In addition, the CNC treated cells displayed inhibition of autophagy, as indicated by reduction of AVOs, decrease in LC3 protein level and up regulation of NBR1 gene expression.